Correlation of the SNP’s of fgfr1 and fgf10 with non-syndromic cleft lip with or without cleft palate in Indian population by DNA sequencing method

Nonsyndromic cleft lip & palate is a congenital deformity of multifactorial origin. Various etiologic candidate genes have been reported with conflicting results, according to the race and population studied. Numerous efforts made understand etiology cleft/palate so as predict its occurrence thus enable prevention. The FGF regulation pathway also plays major role in craniofacial development. FGFR1, FGFR2, FGFR3, FGF10 FGF18 are expressed during various stages secondary Thus their inactivation leads palate.This study was done evaluate association FGFR1 gene variants nonsyndromic palate. DNA samples 25 subjects unrelated controls, collected from department were used for study.The extracted subjected Polymerase chain reaction later sequencing. results documented form electropherogram.The indicated that (rs13317), genotype CC (P=0.02) statistically significant 10 (rs1448037), AA (P< 0.001) highly significant. suggesting strong between NSCLP.